Identifying the DNA binding specificity of chromatin complexes in leukaemia
Molecular Haemopoiesis, London, UK, 2024
Publications
Conference Posters
DNA binding specificity of MLL-AF4 in leukemia
Genome Regulation and Cellular Fates in Homeostasis and Disease, Madrid, Spain, 2024
Journal Articles
Enhancer heterogeneity in acute lymphoblastic leukemia drives differential gene expression between patients
bioRxiv, 2024
This study explores how enhancer variability in ALL patients contributes to divergent gene expression.
The fetal specific gene LIN28B is essential for human fetal B-lymphopoiesis and initiation of KMT2A::AFF1 infant leukemia
bioRxiv, 2024
Shows that LIN28B is critical for fetal B-cell development and initiation of infant leukemia.
MLL-AF4 cooperates with PAF1 and FACT to drive high density enhancer interactions in leukemia
Nature Communications, 2023
Describes how MLL-AF4 collaborates with co-factors to shape enhancer architecture in leukemia.
Endothelial sensing of AHR ligands regulates intestinal homeostasis
Nature, 2023
Demonstrates how endothelial AHR sensing maintains gut homeostasis and barrier function.
Dysregulation of the Pdx1/Ovol2/Zeb2 axis in dedifferentiated β-cells triggers the induction of genes associated with epithelial-mesenchymal transition in diabetes
Molecular Metabolism, 2021
Explores how loss of Pdx1 control in β-cells induces EMT-like gene expression in diabetes.
Conference Papers
The fetal specific gene LIN28B is essential for human fetal B-lymphopoiesis and initiation of KMT2A-AFF1+ infant acute lymphoblastic leukemia
66th American Society of Hematology Annual Meeting, San Diego, CA, USA, 2024
Differential Gene Expression in KMT2A::AFF1 Leukemia Is Driven by Enhancer Heterogeneity
66th American Society of Hematology Annual Meeting, San Diego, CA, USA, 2024
A high-throughput cell culture model of Idiopathic Pulmonary Fibrosis (IPF) for gene therapy applications
25th Annual Meeting of the American Society of Gene & Cell Therapy, Washington, DC, USA, 2022